Description

L-Tryptophan (Indole-D5) is a stable isotope-labeled analog of the essential amino acid L-Tryptophan, where five hydrogen atoms on the indole ring are replaced with deuterium (D). This product is critical for advanced analytical research requiring high specificity and minimal background interference. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors for applications such as metabolic studies and analytical method development.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a crucial quantitative reference in LC-MS and GC-MS analyses for accurate measurement of endogenous L-Tryptophan levels in complex biological matrices.
• Metabolic Pathway Tracing: Used in pharmacokinetic and metabolic flux studies to track the absorption, distribution, metabolism, and excretion (ADME) of tryptophan and its derivatives.
• Proteomics & Biomarker Research: Enables precise, isotope dilution-based quantification of tryptophan-containing peptides and proteins in discovery proteomics and clinical biomarker validation.
• Pharmaceutical Quality Control: Employed in the development and validation of robust analytical methods for drug substance and drug product testing in GMP environments.
• Neuroscience & Neurochemistry Research: Facilitates the study of serotonin and melatonin biosynthesis pathways, aiding research into neurological disorders and sleep physiology.
• Nutritional Science Studies: Used to investigate protein metabolism, amino acid bioavailability, and the role of tryptophan in diet and health supplements.

Basic Information

Item	Detail
Product Name	L-Tryptophan (Indole-D5)
CAS No.	62595-11-3
Molecular Formula	C11H7D5N2O2
Molecular Weight	209.25 g/mol
Synonyms	(2S)-2-Amino-3-(1H-indol-2,4,5,6,7-d5-3-yl)propanoic acid; L-Tryptophan-d5 (Indole ring); Tryptophan-2,4,5,6,7-d5; (S)-Tryptophan-d5; Tryptophan (Indole-d5); Deuterated L-Tryptophan; Tryptophan-d5; L-TRP-d5
EINECS	Contact for details

Quality Control

Every batch of L-Tryptophan (Indole-D5) is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure high chemical purity and isotopic enrichment, typically exceeding 98% (chemical) and 98 atom % D. Certificates of Analysis (COA) detailing results for assay, isotopic purity, chiral purity, and specific impurities are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant use and storage under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.