Description

3-Ethynyl-Indole is a versatile and highly functionalized heterocyclic building block, primarily recognized for its role in advanced organic synthesis. Its core value lies in the presence of both an indole scaffold and a terminal alkyne group, enabling efficient cross-coupling reactions and the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, where it serves as a key precursor for active pharmaceutical ingredients (APIs), functional materials, and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting neurological disorders and oncology.
• Agrochemical Research: Used in the development of new pesticides and herbicides due to its bioactive indole core.
• Material Science: Serves as a monomer or precursor for conductive polymers, organic semiconductors, and advanced functional materials.
• Chemical Synthesis: Employed in Sonogashira, Click, and other palladium-catalyzed cross-coupling reactions to introduce the ethynyl-indole moiety into larger molecules.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and the exploration of new synthetic pathways.
• Ligand Synthesis: Can be utilized to create novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Ethynyl-Indole
CAS No.	62365-78-0
Molecular Formula	C10H7N
Molecular Weight	141.17 g/mol
Synonyms	1H-Indole-3-ethyne; 3-Ethynyl-1H-indole; 3-(Ethynyl)indole; 3-Indolylethyne; Indole-3-ylacetylene; 3-Acetylenylindole; 3-Ethynylindole; 1H-Indole, 3-ethynyl-
EINECS	Contact for details

Quality Control

Our 3-Ethynyl-Indole is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity and purity against established specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.