Description

2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)-3-Phenylpropanoic Acid is a specialized chemical building block featuring a maleimide moiety linked to a phenylpropanoic acid backbone, making it a versatile intermediate for advanced synthesis. This compound is valued for its ability to participate in Michael addition and other conjugation reactions, enabling the creation of functionalized polymers, bioconjugates, and targeted drug delivery systems. It is primarily sought by researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors for developing novel therapeutics and high-performance polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and antibody-drug conjugates (ADCs) via its reactive maleimide group.
• Bioconjugation & Linker Chemistry: Used to create stable thioether bonds with cysteine residues in proteins, peptides, and antibodies for diagnostic and therapeutic applications.
• Polymer Modification & Functionalization: Serves as a cross-linking agent or pendant group to introduce reactive sites or alter the physical properties of polymers and hydrogels.
• Material Science Research: Employed in the development of smart materials, surface coatings, and adhesives requiring specific chemical functionality.
• Peptide Synthesis: Acts as a side-chain protecting group or as a component for constructing complex peptide architectures.
• Chemical Biology Probes: Utilized in the design of activity-based probes and affinity labels for studying enzyme function and protein interactions.

Basic Information

Product Name	2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)-3-Phenylpropanoic Acid
CAS No.	62212-16-2
Molecular Formula	C13H11NO4
Molecular Weight	245.23 g/mol
Synonyms	1-(2-Carboxy-2-phenylethyl)-1H-pyrrole-2,5-dione; 3-Phenyl-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid; N-(2-Carboxy-2-phenylethyl)maleimide; Maleimidophenylpropionic acid; 2-(Maleimid-1-yl)-3-phenylpropionic acid; 1H-Pyrrole-2,5-dione, 1-(2-carboxy-2-phenylethyl)-; Phenylpropanoic acid maleimide derivative
EINECS	Contact for details

Quality Control

Our 2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)-3-Phenylpropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to support your R&D and cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.