Description

8-Chloro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is a versatile and high-value heterocyclic building block, essential for advanced organic synthesis. Its core value lies in its role as a key intermediate for constructing complex pharmacophores, enabling the development of novel active pharmaceutical ingredients (APIs). This compound is critically needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of central nervous system (CNS) active compounds, potential antipsychotics, and other therapeutic agents.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Organic Synthesis Scaffold: Used in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis due to its privileged isoquinoline structure.
• Chemical Biology Probes: Employed in the development of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Fine Chemical Production: Integral to the multi-step synthesis of complex dyes, pigments, and specialty chemicals.

Basic Information

Product Name	8-Chloro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride
CAS No.	61563-33-5
Molecular Formula	C9H10ClN•HCl
Molecular Weight	204.10 g/mol
Synonyms	8-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 8-Chloro-1,2,3,4-tetrahydroisoquinoline HCl; 8-Chloro-1,2,3,4-tetrahydro-isoquinoline monohydrochloride; 8-Chloro-THIQ hydrochloride; 8-Cl-THIQ•HCl; 8-Chloro-3,4-dihydro-1H-isoquinoline hydrochloride; 1,2,3,4-Tetrahydro-8-chloroisoquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our 8-Chloro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.