Description

trans-2-(Iodomethyl)-1,3-Dioxolane-4-Methanol is a versatile iodinated dioxolane derivative, serving as a crucial chiral building block and intermediate in advanced organic synthesis. Its value lies in its reactive iodomethyl group and protected diol functionality, enabling precise stereochemical control in the construction of complex molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of antiviral agents, nucleoside analogs, and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and plant growth regulators with specific stereochemistry.
• Ligand and Catalyst Preparation: Used in the development of chiral ligands and organocatalysts for asymmetric synthesis.
• Polymer Chemistry: Monomer or cross-linking agent for producing specialty polymers with unique properties.
• Material Science Research: Intermediate in the development of liquid crystals, advanced coatings, and other functional materials.
• Academic & Process R&D: Valuable reagent for methodological studies in organic chemistry and scale-up process development.

Basic Information

Product Name	trans-2-(Iodomethyl)-1,3-Dioxolane-4-Methanol
CAS No.	61508-57-4
Molecular Formula	C5H9IO3
Molecular Weight	244.03 g/mol
Synonyms	4-(Hydroxymethyl)-2-(iodomethyl)-1,3-dioxolane (trans-); (2R,4S)- and (2S,4R)-2-(Iodomethyl)-4-(hydroxymethyl)-1,3-dioxolane; 1,3-Dioxolane-4-methanol, 2-(iodomethyl)-, trans-; Iodomethyl dioxolane methanol; trans-2-Iodomethyl-4-hydroxymethyl-1,3-dioxolane; Chiral iododioxolane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), enantiomeric excess, and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.