Description

Dl-Mevalonic-Methyl-D3 Lactone is a deuterated isotopologue of mevalonolactone, a key intermediate in the biosynthesis of isoprenoids and sterols. This labeled compound is essential for metabolic pathway tracing and analytical method development, providing critical insights into biochemical mechanisms. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries for use as a stable isotope-labeled internal standard in mass spectrometry and NMR studies.

Application

• Internal standard for the quantitative analysis of mevalonic acid and related metabolites via LC-MS or GC-MS.
• Tracer compound in metabolic flux analysis (MFA) studies of the mevalonate pathway.
• Key labeled intermediate in the research and development of novel cholesterol-lowering drugs or other isoprenoid-based therapeutics.
• Use in pharmacokinetic and pharmacodynamic studies to track drug metabolism and distribution.
• Reference material for the calibration of analytical instruments in quality control laboratories.
• Precursor in the synthesis of deuterated terpenes, steroids, or other complex natural products for research purposes.

Basic Information

Product Name	Dl-Mevalonic-Methyl-D3 Lactone
CAS No.	61219-76-9
Molecular Formula	C6H7D3O3
Molecular Weight	133.16 g/mol
Synonyms	3-Methyl-D3-dihydro-4-hydroxy-2H-pyran-2-one; (±)-Mevalonolactone-methyl-d3; DL-Mevalonolactone-methyl-d3; 3,5-Dihydroxy-3-methyl-D3-pentanoic acid δ-lactone; Mevalolactone-methyl-d3; 5-Methyl-D3-5-hydroxy-3-oxopentanoic acid lactone; 4-Hydroxy-3-methyl-D3-4,5-dihydro-2H-pyran-2-one
EINECS	Contact for details

Quality Control

Our Dl-Mevalonic-Methyl-D3 Lactone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment, chemical purity, and structural identity. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and impurity profile are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D (Methyl-D3)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.