Description

Levorphanol Sulfate is the sulfate salt form of levorphanol, a potent synthetic opioid analgesic. This compound is critical for pharmaceutical research and development, offering a high-affinity ligand for opioid receptor studies and serving as a key reference standard. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in neuropharmacology, pain management research, and quality control of related pharmaceutical products.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification, purity assay, and quantification of levorphanol in drug substances and finished dosage forms.
• Analytical Research: Used in method development and validation for chromatographic (HPLC, GC) and spectroscopic analyses in forensic and clinical toxicology.
• Neuropharmacological Studies: Employed as a research chemical to investigate the binding kinetics, efficacy, and signaling pathways of opioid receptors (mu, kappa, delta).
• Preclinical Development: Acts as a key intermediate or active pharmaceutical ingredient (API) in the development of novel analgesic formulations and delivery systems.
• Quality Control & Assurance: Essential for in-house QC laboratories to ensure the identity, strength, quality, and purity of opioid-based medications.

Basic Information

Product Name	Levorphanol Sulfate
CAS No.	61095-53-2
Molecular Formula	C17H23NO · H2SO4
Molecular Weight	443.53 g/mol
Synonyms	Levorphanol Sulphate; (-)-3-Hydroxy-N-methylmorphinan Sulfate; Levo-Dromoran Sulfate; Ro 1-5470/5; NSC 25141; 17-Methylmorphinan-3-ol Sulfate; (9α,13α,14α)-17-Methylmorphinan-3-ol Sulfate
EINECS	Contact for details

Quality Control

Our Levorphanol Sulfate is manufactured and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided, which includes data for identity, purity, and related substances as determined by advanced techniques like HPLC and NMR. We adhere to relevant guidelines for reference standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.