Description

Choline Chloride (Trimethyl-D9) is a stable isotope-labeled analog of the essential nutrient choline, where nine hydrogen atoms in the three methyl groups are replaced by deuterium. This high-purity standard is critical for ensuring accuracy and reliability in quantitative analytical methods. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, nutritional science, and metabolomics fields who require definitive internal standards for mass spectrometry and NMR studies.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for the precise quantification of choline and its metabolites in complex biological matrices like plasma, urine, and tissue samples.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Used as a tracer in metabolic pathway studies to investigate choline metabolism and related biochemical processes.
• Pharmaceutical Research & Development: Supports drug metabolism and pharmacokinetics (DMPK) studies for compounds affecting cholinergic pathways.
• Clinical Diagnostics: Enables accurate measurement of choline levels for research into conditions like fatty liver disease, neurological disorders, and cancer.
• Nutritional Science: Facilitates the study of choline absorption, bioavailability, and its role in human health and development.
• Method Development & Validation: Serves as a key reference material for developing and validating robust LC-MS/MS and GC-MS analytical methods.

Basic Information

Product Name	Choline Chloride (Trimethyl-D9)
CAS No.	61037-86-3
Molecular Formula	C5D9ClNO
Molecular Weight	147.64 g/mol
Synonyms	(2-Hydroxyethyl)trimethyl-d9-ammonium Chloride; Choline-d9 Chloride; Deuterated Choline Chloride; Choline Chloride-d9; Trimethyl-d9-(2-hydroxyethyl)ammonium Chloride; (β-Hydroxyethyl)trimethyl-d9-ammonium Chloride; Biocolina-d9; Hepacholine-d9
EINECS	Contact for details

Quality Control

Every batch of our Choline Chloride (Trimethyl-D9) is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, isotopic enrichment (D-content), and identification. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.