Description

Phenacetin-D3 is a stable isotope-labeled analog of the analgesic compound phenacetin, specifically deuterated at three positions. This product is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities for drug metabolism and pharmacokinetic (DMPK) studies, bioanalytical method development, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of phenacetin and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) research to track and measure parent drug and metabolite levels.
• Bioanalytical Method Development and Validation: Serves as a reference compound to establish selectivity, sensitivity, accuracy, and precision of analytical assays.
• Forensic and Clinical Toxicology: Enables accurate screening and confirmation of phenacetin in forensic investigations or clinical case studies.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Provides reliable data input for modeling drug behavior in the body.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating methods for pharmaceutical formulations.

Basic Information

Product Name	Phenacetin-D3
CAS No.	60902-27-4
Molecular Formula	C10H10D3NO2
Molecular Weight	182.23 g/mol
Synonyms	N-(4-Ethoxyphenyl)acetamide-d3; 4'-Ethoxyacetanilide-d3; Acetophenetidin-d3; p-Acetophenetidide-d3; 1-Acetamido-4-ethoxybenzene-d3; N-Acetyl-p-phenetidine-d3; Phenacetin (ethyl-d3)
EINECS	Contact for details

Quality Control

Every batch of Phenacetin-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing batch-specific results for identity, purity, isotopic enrichment, and solvent residues are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product under inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.