Description

2-Bromo-5-Trifluoromethylbenzenethiol is a high-value organosulfur building block characterized by its unique combination of bromine and trifluoromethyl substituents on a thiophenol core. This compound is essential for introducing sulfur-based functionalities and fluorinated aromatic motifs into complex molecular architectures. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for applications in drug discovery, material science, and the synthesis of advanced chemical intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring thioether linkages or fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the bromine atom offers a site for further cross-coupling reactions and the CF3 group improves lipophilicity.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis, leveraging the thiol group for metal coordination.
• Material Science Research: Acts as a monomer or modifying agent in the creation of advanced polymers and functional materials with specific electronic or surface properties.
• Organic Synthesis Building Block: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic aromatic substitution reactions to construct complex, multi-functional molecules.

Basic Information

Product Name	2-Bromo-5-Trifluoromethylbenzenethiol
CAS No.	60877-19-2
Molecular Formula	C7H4BrF3S
Molecular Weight	257.07 g/mol
Synonyms	2-Bromo-α,α,α-trifluoro-p-thiocresol; 2-Bromo-5-(trifluoromethyl)benzenethiol; 2-Bromo-5-(trifluoromethyl)thiophenol; 1-Bromo-4-mercapto-2-(trifluoromethyl)benzene; 2-Bromo-α,α,α-trifluoro-p-toluenethiol; Benzenethiol, 2-bromo-5-(trifluoromethyl)-; p-(Trifluoromethyl)-2-bromobenzenethiol
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Trifluoromethylbenzenethiol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.