Description

3-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is a protected indazole derivative that serves as a versatile and critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a reactive bromine handle and a protected nitrogen site, enabling precise and sequential functionalization for building complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who are developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of drug candidates, particularly those targeting kinase inhibition and other biological pathways where the indazole scaffold is privileged.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require halogenated heterocyclic cores for enhanced bioactivity.
• Organic Synthesis: Serves as a pivotal precursor for cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitutions to introduce diverse functional groups.
• Material Science: Potential monomer or precursor for creating specialized polymers and organic electronic materials with tailored properties.
• Chemical Biology: Utilized in the design and synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Academic & R&D: Fundamental reagent in methodological studies and the exploration of new synthetic routes in heterocyclic chemistry.

Basic Information

Product Name	3-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole
CAS No.	60869-95-6
Molecular Formula	C₁₂H₁₃BrN₂O
Molecular Weight	281.15 g/mol
Synonyms	3-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 3-Bromo-1-THP-indazole; 1H-Indazole, 3-bromo-1-(tetrahydro-2H-pyran-2-yl)-; 3-Bromo-1-(2-tetrahydropyranyl)-1H-indazole; 3-Bromo-1-THP-1H-indazole; 3-Br-1-THP-indazole; THP-protected 3-bromoindazole
EINECS	Contact for details

Quality Control

Our 3-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.