Description

Thiofentanil is a potent synthetic opioid analgesic compound, structurally related to fentanyl. Its primary significance lies in its application as a key intermediate or reference standard in advanced pharmaceutical research and analytical chemistry. This compound is essential for researchers and developers in the pharmaceutical and forensic science industries, particularly for studies involving opioid receptor pharmacology, metabolic pathway analysis, and the development of detection methodologies.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate or reference standard in the synthesis and study of novel opioid analgesics and their antagonists.
• Forensic Analysis & Toxicology: Used as an analytical reference standard for the identification and quantification of fentanyl analogs in forensic and clinical toxicology laboratories.
• Biochemical Research: Employed in in vitro studies to investigate binding affinities, potencies, and metabolic pathways at opioid receptors.
• Controlled Substance Monitoring: Acts as a calibration standard for law enforcement and regulatory agencies monitoring illicit drug markets.
• Method Development & Validation: Essential for developing and validating sensitive analytical methods such as LC-MS/MS, GC-MS, and HPLC for opioid detection.
• Academic Studies: Utilized in university and institutional research programs focused on neuropharmacology and medicinal chemistry.

Basic Information

Product Name	Thiofentanil
CAS No.	60771-38-2
Molecular Formula	C₂₃H₃₀N₂O₂S
Molecular Weight	398.56 g/mol
Synonyms	Thiofentanyl; 4-(Methoxycarbonyl)-4-(N-phenethyl-1-piperidinyl)thioacetamilide; N-[1-(2-Phenylethyl)-4-piperidinyl]-N-phenyl-2-(methylthio)acetamide; 2-(Methylthio)-N-[1-(2-phenylethyl)-4-piperidinyl]-N-phenylacetamide; 4'-Methylthio-fentanyl; 2-Methylthiofentanyl; NSC 758502
EINECS	Contact for details

Quality Control

Our Thiofentanil is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for reference materials, and specifications can be provided to meet specific research protocol requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.