Description

4-Bromo-5-Chlorothiophene-2-Carboxylic Acid is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters as a critical intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific halogenated thiophene motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the thiophene core contributes to biological activity.
• Material Science Precursor: Serves as a monomer or building block for conducting polymers, organic semiconductors, and nonlinear optical (NLO) materials.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for transition metal catalysis and organocatalysts.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.
• Academic and Industrial R&D: Utilized in discovery chemistry for library synthesis and structure-activity relationship (SAR) studies.

Basic Information

Item	Details
Product Name	4-Bromo-5-Chlorothiophene-2-Carboxylic Acid
CAS No.	60729-37-5
Molecular Formula	C5H2BrClO2S
Molecular Weight	241.49 g/mol
Synonyms	5-Chloro-4-bromothiophene-2-carboxylic acid; 2-Bromo-3-chlorothiophene-5-carboxylic acid; 4-Bromo-5-chloro-2-thiophenecarboxylic acid; 4-Bromo-5-chlorothiophene-2-carboxylic acid; 2-Thiophenecarboxylic acid, 4-bromo-5-chloro-; Thiophene-2-carboxylic acid, 4-bromo-5-chloro-; 4-Bromo-5-chloro-thiophene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Chlorothiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our standard grades meet the stringent requirements for research and process development, with custom purity levels (e.g., >97%, >98%, >99%) available to support your specific project phase from discovery to scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.