Description

3,4‐Dihydroxyphenyl‐D3‐Acetic‐2,2‐D2 Acid is a stable isotope-labeled analog of homoprotocatechuic acid, specifically deuterated at key positions. This high-purity compound is essential for creating internal standards in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical data. It is critically needed by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories for drug metabolism and pharmacokinetic (DMPK) studies, biomarker quantification, and advanced proteomics research.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for bioanalytical method development and validation.
• Drug Metabolism Studies (DMPK): Enables precise tracking and quantification of metabolites in in vitro and in vivo studies to understand drug clearance pathways.
• Biomarker Research: Used in the accurate measurement of endogenous catecholamine metabolites and related phenolic acids in clinical and preclinical samples.
• Proteomics & Metabolomics: Facilitates stable isotope dilution analysis for the absolute quantification of proteins and small molecules in complex biological matrices.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for APIs and finished drug products containing related chemical structures.
• Isotope-Labeled Intermediate: Serves as a building block for the synthesis of more complex deuterated compounds for research and diagnostic applications.

Basic Information

Product Name	3,4‐Dihydroxyphenyl‐D3‐Acetic‐2,2‐D2 Acid
CAS No.	60696-39-1
Molecular Formula	C8H3D5O4
Molecular Weight	171.18 g/mol (for labeled form)
Synonyms	Homoprotocatechuic Acid-d5; 3,4-Dihydroxyphenylacetic-2,2-d2-α,β,β-d3 Acid; (3,4-Dihydroxyphenyl)acetic-d5 Acid; 3,4-DHPA-d5; HPA-d5; 2-(3,4-Dihydroxyphenyl)acetic-2,2,α,β,β-d5 Acid; Deuterated Homoprotocatechuic Acid; D5-Homoprotocatechuic Acid
EINECS	Contact for details

Quality Control

Every batch of our 3,4‐Dihydroxyphenyl‐D3‐Acetic‐2,2‐D2 Acid is manufactured and tested under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and mass spectrometry for isotopic enrichment verification. Certificates of Analysis (COA) detailing purity, assay, and isotopic abundance are provided with each shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.