Description

(R)-(-)-1-Aminoethyl-Phosphonic Acid CAS NO 60687-36-7 is a chiral, non-proteinogenic amino acid analog where the carboxylic acid group is replaced by a phosphonic acid moiety. This structural feature makes it a valuable building block and a potent enzyme inhibitor, particularly for glutamate decarboxylase and other PLP-dependent enzymes. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients, chiral catalysts, and biochemical probes. Its unique stereochemistry and bioisosteric properties are leveraged in drug discovery and the synthesis of specialized peptides.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel drugs, including enzyme inhibitors and receptor modulators.
• Agrochemical Research: Used in the synthesis of herbicidal and plant growth regulatory compounds due to its phosphonate group's bioactivity.
• Biochemical Research: Serves as a selective inhibitor in enzymatic studies, particularly for glutamate decarboxylase (GAD) and other pyridoxal phosphate-dependent enzymes.
• Chiral Catalyst & Ligand Synthesis: Building block for creating phosphonic acid-based ligands used in asymmetric catalysis.
• Peptidomimetics: Incorporated into peptide analogs to enhance metabolic stability and modulate biological activity.
• Reference Standard: Used as a high-purity analytical standard in quality control and method development for chiral analysis.

Basic Information

Item	Details
Product Name	(R)-(-)-1-Aminoethyl-Phosphonic Acid
CAS No.	60687-36-7
Molecular Formula	C2H8NO3P
Molecular Weight	125.06 g/mol
Synonyms	(R)-1-Aminoethylphosphonic Acid; D-1-Aminoethylphosphonic Acid; (R)-AEP; (R)-AEPn; (R)-1-AEP; (R)-Phosphonalanine; (R)-2-Aminoethylphosphonic Acid (less common); ARP
EINECS	Contact for details

Quality Control

Every batch of (R)-(-)-1-Aminoethyl-Phosphonic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your research or cGMP starting material requirements. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (HPLC), chiral purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.