Description

Lofentanil is a potent synthetic opioid analgesic belonging to the 4-anilidopiperidine class. Its exceptional potency makes it a critical compound for advanced pharmacological research and development. This product is primarily utilized by pharmaceutical R&D laboratories and forensic science institutions for specialized studies. Lofentanil CAS NO 60645-00-3 is handled under strict regulatory controls due to its nature.

Application

• Pharmacological Research: Used in preclinical studies to investigate the mechanisms of ultra-potent opioid action, receptor binding affinity, and structure-activity relationships (SAR).
• Analytical Reference Standard: Serves as a high-purity certified reference material (CRM) for forensic analysis, toxicology screening, and method development in mass spectrometry and chromatography.
• Neurochemical Studies: Employed in research focused on the central nervous system (CNS), pain pathways, and the development of novel analgesic agents or opioid antagonists.
• Biochemical Assay Development: Acts as a key ligand in the development and validation of competitive binding assays and other in vitro test systems for opioid receptors.

Basic Information

Product Name	Lofentanil
CAS No.	60645-00-3
Molecular Formula	C23H32N2O3
Molecular Weight	384.52 g/mol
Synonyms	Lofentanil; Lofentanil Oxalate; R-34995; (±)-Lofentanil; 4-[(N-Phenethyl-4-piperidinyl)amino]-N-phenylpentanamide; N-Phenethyl-4-(N-phenylpentanamido)piperidine
EINECS	Contact for details

Quality Control

Every batch of our Lofentanil is synthesized and purified under controlled conditions to ensure the highest standards of identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing comprehensive analytical results, including chromatographic purity and identity confirmation, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.