Description

2-(2-Chloro-Acetylamino)-4,5-Dimethyl-Thiophene-3-Carboxylic Acid Ethyl Ester is a high-purity, multi-functional organic intermediate of significant importance in advanced chemical synthesis. Its core value lies in its role as a versatile building block for constructing complex heterocyclic molecules, particularly in the pharmaceutical sector. This compound is essential for research and development chemists and production units engaged in creating active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel thiophene-based drug candidates, including potential anti-inflammatory, antimicrobial, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for enhanced biological activity.
• Material Science Research: Serves as a monomer or functional unit in the research of organic semiconductors, conductive polymers, and other specialty materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex heterocyclic dyes and organic pigments.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs) developing proprietary compounds.
• Academic & Industrial R&D: Utilized in universities and corporate labs for methodological development and exploring new chemical entities.

Basic Information

Product Name	2-(2-Chloro-Acetylamino)-4,5-Dimethyl-Thiophene-3-Carboxylic Acid Ethyl Ester
CAS No.	60442-34-4
Molecular Formula	C12H14ClNO3S
Molecular Weight	287.76 g/mol
Synonyms	Ethyl 2-[(2-chloroacetyl)amino]-4,5-dimethylthiophene-3-carboxylate; 2-(2-Chloroacetamido)-4,5-dimethylthiophene-3-carboxylic acid ethyl ester; 4,5-Dimethyl-2-[(2-chloroacetyl)amino]thiophene-3-carboxylic acid ethyl ester; 2-Acetamido-4,5-dimethylthiophene-3-carboxylic acid ethyl ester, 2-chloro-; N-(2-Chloroacetyl)-4,5-dimethyl-2-aminothiophene-3-carboxylic acid ethyl ester; 60442-34-4; AKOS BBS-00007316
EINECS	Contact for details

Quality Control

Our production of 2-(2-Chloro-Acetylamino)-4,5-Dimethyl-Thiophene-3-Carboxylic Acid Ethyl Ester adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.