Description

(4R)-4α-Ethyl-1,3,4,4Aβ,5,7,12,12Aβ-Octahydro-2-Methylpyrido[3',4':4,5]Cyclohept[1,2-B]Indol-6(2H)-One is a complex, stereochemically defined heterocyclic compound that serves as a critical advanced intermediate in modern organic synthesis. Its intricate fused ring system makes it a valuable building block for constructing pharmacologically active molecules, particularly in the development of novel alkaloid-based therapeutics. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and fine chemical industries seeking to streamline complex synthetic routes and ensure stereochemical fidelity in their final active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex natural product analogs and novel drug candidates targeting the central nervous system.
• Alkaloid Synthesis: Used as a sophisticated scaffold for constructing indole and pyridine-fused alkaloid structures with potential biological activity.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space.
• Process Chemistry Development: Serves as a benchmark compound for developing and scaling up efficient, stereoselective manufacturing processes.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and asymmetric synthesis.
• Fine Chemical Production: Acts as a specialized intermediate for producing high-value, low-volume chemicals for advanced applications.

Basic Information

Product Name	(4R)-4α-Ethyl-1,3,4,4Aβ,5,7,12,12Aβ-Octahydro-2-Methylpyrido[3',4':4,5]Cyclohept[1,2-B]Indol-6(2H)-One
CAS No.	60426-50-8
Molecular Formula	C19H24N2O
Molecular Weight	296.41 g/mol
Synonyms	4a-Ethyl-2-methyl-1,3,4,4a,5,7,12,12a-octahydropyrido[3',4':4,5]cyclohepta[1,2-b]indol-6(2H)-one, (4R)-rel-4a-Ethyl-1,3,4,4a,5,7,12,12a-octahydro-2-methylpyrido[3',4':4,5]cyclohepta[1,2-b]indol-6(2H)-one, Pyridocycloheptaindolone derivative, Advanced indole alkaloid intermediate
EINECS	Contact for details

Quality Control

Every batch of (4R)-4α-Ethyl-1,3,4,4Aβ,5,7,12,12Aβ-Octahydro-2-Methylpyrido[3',4':4,5]Cyclohept[1,2-B]Indol-6(2H)-One is manufactured under strict quality management systems to ensure identity, purity, and consistency. Our products undergo rigorous analytical testing, including chiral HPLC, to confirm stereochemical purity and meet exacting research-grade specifications. Comprehensive Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.