Description

Atropine-D3 is a deuterium-labeled analog of the naturally occurring tropane alkaloid atropine, specifically designed for use as an internal standard in analytical chemistry. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics industries, where precise measurement of atropine and its metabolites is required.

Application

• Internal Standard for LC-MS/MS: Primary application for the precise quantification of atropine in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical Research & Development: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track drug metabolism and bioavailability.
• Forensic Toxicology: Enables accurate measurement of atropine in cases of poisoning or drug overdose investigations.
• Clinical Diagnostics: Supports the development and validation of diagnostic assays for therapeutic drug monitoring.
• Method Development & Validation: Serves as a critical reference material for developing robust, high-precision analytical methods.
• Quality Control in Manufacturing: Used to verify the purity and concentration of atropine in pharmaceutical formulations.

Basic Information

Product Name	Atropine-D3
CAS No.	60365-55-1
Molecular Formula	C17H20D3NO3
Molecular Weight	292.40 g/mol
Synonyms	(±)-Hyoscyamine-d3; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate-d3; Tropine tropate-d3; DL-Hyoscyamine-d3; Atropine (phenyl-d3); Atropine-d3 (deuterated); Atropine internal standard
EINECS	Contact for details

Quality Control

Our Atropine-D3 is produced under strict quality management protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.