Description

(+/-)-Methadone-D3 CAS NO 60263-63-0 is a deuterated internal standard of the synthetic opioid analgesic, methadone, where three hydrogen atoms are replaced with deuterium. This stable isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative analytical methods. It is a critical reagent for researchers and quality control laboratories in pharmaceutical development, forensic toxicology, and clinical research, where precise measurement of methadone and its metabolites is required.

Application

• Internal Standard for Mass Spectrometry (MS): Primary use as a quantitative internal standard in GC-MS and LC-MS/MS analysis for methadone, correcting for instrument variability and sample preparation losses.
• Pharmaceutical Research & Development: Used in pharmacokinetic studies, metabolism research, and bioanalytical method development for methadone-based therapies.
• Forensic and Clinical Toxicology: Enables precise quantification of methadone in biological matrices (blood, urine, hair) for drug monitoring, overdose investigations, and compliance testing.
• Reference Standard Manufacturing: Serves as a certified reference material (CRM) for calibrating analytical instruments and validating test methods.
• Doping Control Analysis: Employed in sports anti-doping laboratories to accurately detect and confirm the presence of methadone.
• Regulatory Compliance Testing: Supports analytical testing for compliance with FDA, EMA, and other global regulatory guidelines for controlled substances.

Basic Information

Product Name	(+/-)-Methadone-D3
CAS No.	60263-63-0
Molecular Formula	C21H24D3NO
Molecular Weight	312.47 g/mol
Synonyms	Methadone-d3; (±)-Methadone-d3; DL-Methadone-d3; 6-(Dimethylamino)-4,4-diphenyl-3-heptanone-d3; Racemic Methadone-d3; Methadone (phenyl-d3); 4,4-Diphenyl-6-(dimethylamino)-3-heptanone-d3; SKF-5135-d3
EINECS	Contact for details

Quality Control

Every batch of (+/-)-Methadone-D3 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use as a high-purity reference standard. Certificates of Analysis (COA) are supplied with each shipment, detailing results for identity, purity (by HPLC), isotopic enrichment, and residual solvents. Our quality commitment ensures compliance with the standards expected in pharmaceutical and forensic analysis.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.