Description

(E)-1-(Trimethylsilyl)-3-Hexen-1-Yne is a specialized organosilicon building block featuring both a terminal alkyne and an alkene functionality. This unique bifunctional structure makes it a valuable reagent for advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel compounds and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring conjugated alkyne-alkene systems.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its reactivity for structural diversification.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialized polymers and silicon-containing advanced materials.
• Organic Synthesis Reagent: Employed in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to introduce the trimethylsilyl-protected alkyne moiety.
• Ligand and Catalyst Development: Useful for constructing complex organic ligands used in homogeneous catalysis.
• Chemical Research: A versatile tool in academic and industrial R&D for exploring new synthetic methodologies and constructing molecular libraries.

Basic Information

Product Name	(E)-1-(Trimethylsilyl)-3-Hexen-1-Yne
CAS No.	60216-44-6
Molecular Formula	C9H16Si
Molecular Weight	152.31 g/mol
Synonyms	1-Trimethylsilyl-3-hexen-1-yne (E); (E)-3-Hexen-1-yn-1-yltrimethylsilane; 3-Hexen-1-yn-1-yltrimethylsilane, (E)-; TMS-Protected Enyne; Trimethyl((3E)-3-hexen-1-yn-1-yl)silane; 1-Trimethylsilyl-1-hexen-3-yne; (E)-1-Hexen-3-yn-1-yltrimethylsilane
EINECS	Contact for details

Quality Control

Our production of (E)-1-(Trimethylsilyl)-3-Hexen-1-Yne adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is analyzed using advanced techniques including GC, GC-MS, and NMR to confirm identity, isomeric purity ((E)-isomer), and chemical composition. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Isomeric Purity ((E)-isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.