Description

4-Hydroxyvalproate is a key pharmaceutical intermediate and metabolite of the anticonvulsant drug valproic acid. Its precise chemical structure makes it a critical reference standard and building block for advanced research and synthesis. This compound is essential for organizations in the pharmaceutical, biotechnology, and analytical chemistry sectors requiring high-purity materials for drug development, metabolism studies, and quality control.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of valproic acid derivatives and related central nervous system (CNS) drugs.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method validation, calibration, and quality assurance of drug products.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism, efficacy, and safety profile of valproic acid.
• Biochemical Research: Serves as a tool compound in neuroscience and pharmacology research to investigate mechanisms of action and therapeutic pathways.
• Impurity Standard: Used to identify, quantify, and control related substances in valproic acid and sodium valproate active pharmaceutical ingredient (API) manufacturing.
• Custom Synthesis: A starting material for the custom synthesis of novel chemical entities and labeled compounds for diagnostic or research purposes.

Basic Information

Product Name	4-Hydroxyvalproate
CAS No.	60113-82-8
Molecular Formula	C8H14O3
Molecular Weight	158.20 g/mol
Synonyms	4-Hydroxy-2-propylpentanoic Acid; 2-Propyl-4-hydroxypentanoic Acid; 4-Hydroxyvalproic Acid; Valproic Acid Metabolite IV; 4-OH-VPA; 4-Hydroxy-2-propylvaleric Acid; 4-HV; 2-Propyl-4-hydroxypentanoate
EINECS	Contact for details

Quality Control

Our 4-Hydroxyvalproate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and GC. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, ensuring compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.