Description

9H-Pyrrolo[1,2-A]Indol-9-One,1,2,3,5,6,7,8,9A-Octahydro-,(S)-(9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound matters for its role as a critical chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its specific stereochemistry is essential for biological activity. Pharmaceutical R&D and manufacturing teams need this intermediate for developing and producing novel therapeutic agents, particularly in central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly for neurological and oncological targets.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct intricate molecular architectures found in modern pharmaceuticals.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in API manufacturing.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for custom synthesis projects.

Basic Information

Product Name	9H-Pyrrolo[1,2-A]Indol-9-One,1,2,3,5,6,7,8,9A-Octahydro-,(S)-(9Ci)
CAS No.	60026-39-3
Molecular Formula	C11H15NO
Molecular Weight	177.24 g/mol
Synonyms	(S)-1,2,3,5,6,7,8,9a-Octahydro-9H-pyrrolo[1,2-a]indol-9-one; (S)-Octahydropyrrolo[1,2-a]indol-9-one; (9aS)-Octahydro-9H-pyrrolo[1,2-a]indol-9-one; (S)-Perhydro-9H-pyrrolo[1,2-a]indol-9-one; (S)-Hexahydro-1H-pyrrolizine-7a(5H)-one (related fused system); Pyrrolo[1,2-a]indole-9-one, octahydro-, (S)-; (S)-9H-Pyrrolo[1,2-a]indol-9-one, octahydro-
EINECS	Contact for details

Quality Control

Our 9H-Pyrrolo[1,2-A]Indol-9-One,1,2,3,5,6,7,8,9A-Octahydro-,(S)-(9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the stringent requirements of pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.