Description

6β-Nalbuphine Hydrochloride is a potent semi-synthetic opioid analgesic and antagonist. This compound is of significant interest in pharmaceutical research and development due to its unique mixed agonist-antagonist profile, offering analgesic effects with a potentially lower risk of respiratory depression and abuse compared to pure μ-opioid agonists. It is primarily utilized by pharmaceutical manufacturers and research institutions for the development of injectable pain management solutions and in advanced pharmacological studies targeting opioid receptor modulation.

Application

• Active Pharmaceutical Ingredient (API) for injectable analgesic formulations.
• Reference Standard in analytical chemistry and quality control laboratories for drug testing.
• Pharmacological Research for studying mixed opioid agonist-antagonist mechanisms and receptor binding.
• Preclinical Development of novel pain management therapies with improved safety profiles.
• Chemical Intermediate in the synthesis of more complex opioid-derived compounds for research purposes.

Basic Information

Product Name	6β-Nalbuphine Hydrochloride
CAS No.	60018-68-0
Molecular Formula	C21H27NO4 • HCl
Molecular Weight	393.91 g/mol (Free base: 357.45 g/mol)
Synonyms	Nalbuphine Hydrochloride; 17-(Cyclobutylmethyl)-4,5α-epoxy-3,6α,14-trihydroxymorphinan-6-one Hydrochloride; EN-2234A; Nalbuphine HCl; (-)-17-(Cyclobutylmethyl)-4,5α-epoxymorphinan-3,6α,14-triol Hydrochloride; 6β-Nalbuphine Hydrochloride; Nubain® (brand name equivalent, as hydrochloride salt)
EINECS	Contact for details

Quality Control

Our 6β-Nalbuphine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high-grade standards suitable for research and development applications. A Certificate of Analysis (COA) detailing specific results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.