Description

2,2,2-Trichloroethyl Phosphorodichloridite is a specialized organophosphorus reagent primarily used as a key intermediate in the synthesis of complex molecules. Its value lies in its unique reactivity as a phosphitylating agent, enabling the efficient construction of phosphate esters and phosphoramidites under controlled conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing nucleotide analogs, ligands, and flame retardants.

Application

• Phosphoramidite Synthesis: A critical precursor in the production of phosphoramidites for oligonucleotide (DNA/RNA) synthesis, supporting pharmaceutical and diagnostic research.
• Phosphate Ester Production: Used as a phosphorylating agent to create specialized phosphate esters with applications as flame retardants, plasticizers, and extractants.
• Ligand and Catalyst Preparation: Serves as a building block for synthesizing chiral phosphite and phosphoramidite ligands used in asymmetric catalysis.
• Agrochemical Intermediate: Employed in the manufacture of certain organophosphate-based active ingredients for crop protection products.
• Polymer Modification: Utilized to introduce phosphorus-containing functional groups into polymer chains to impart flame-retardant properties.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in medicinal chemistry and material science.

Basic Information

Product Name	2,2,2-Trichloroethyl Phosphorodichloridite
CAS No.	60010-51-7
Molecular Formula	C2H2Cl5OP
Molecular Weight	248.27 g/mol
Synonyms	Phosphorodichloridous Acid 2,2,2-Trichloroethyl Ester; 2,2,2-Trichloroethyl Phosphorodichloridite; Trichloroethyl Phosphorodichloridite; Dichloro(2,2,2-trichloroethoxy)phosphine; (2,2,2-Trichloroethoxy)phosphonous Dichloride; O-(2,2,2-Trichloroethyl) Phosphorodichloridite
EINECS	Contact for details

Quality Control

Our 2,2,2-Trichloroethyl Phosphorodichloridite is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including assay by titration and impurity profiling by GC or HPLC. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong oxidizers and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/Titration)	≥ 95.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.