Description

2-Cyano-3-Indol-3-Yl-Acrylic Acid Amide is a specialized heterocyclic building block featuring a cyanoacrylamide moiety fused to an indole ring system. This unique molecular architecture makes it a valuable intermediate for synthesizing complex organic molecules, particularly in medicinal chemistry and materials science. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel compounds with targeted biological or photophysical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, receptor antagonists, and other bioactive molecules targeting various disease pathways.
• Agrochemical Research: Used in developing novel active ingredients for crop protection products, leveraging its heterocyclic structure.
• Organic Electronics: Serves as a building block for organic semiconductors, light-emitting diodes (OLEDs), and other functional materials due to its conjugated system.
• Fluorescent Probe Synthesis: The indole and cyanoacrylamide structure is utilized to create fluorescent dyes and sensors for biological imaging and diagnostics.
• Academic & Contract Research: Employed in universities and CROs for methodological studies and the discovery of new chemical entities.
• Peptidomimetics: Acts as a constrained scaffold in the design of peptide mimics to enhance metabolic stability and bioavailability.

Basic Information

Product Name	2-Cyano-3-Indol-3-Yl-Acrylic Acid Amide
CAS No.	6940-85-8
Molecular Formula	C₁₂H₉N₃O
Molecular Weight	211.22 g/mol
Synonyms	2-Cyano-3-(1H-indol-3-yl)acrylamide; 3-(2-Cyano-2-carbamoylvinyl)indole; (2Z)-2-Cyano-3-(1H-indol-3-yl)prop-2-enamide; 3-Indolylidenemalononitrile monoamide; 2-Cyano-3-(3-indolyl)acrylamide; Acrylamide, 2-cyano-3-(3-indolyl)-; NSC 163022
EINECS	Contact for details

Quality Control

Our 2-Cyano-3-Indol-3-Yl-Acrylic Acid Amide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	Yellow to brown powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.