Description

Isobutyric Acid Sodium Salt, [Carboxyl-14C] CAS NO 6917-21-1 is a carbon-14 labeled isotopologue of sodium isobutyrate, a key compound for advanced metabolic and pharmacokinetic research. This radiolabeled tracer is essential for precise tracking of isobutyrate pathways in biological systems, enabling definitive studies on fatty acid metabolism and gut microbiome interactions. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions conducting high-impact metabolic and ADME (Absorption, Distribution, Metabolism, and Excretion) studies.

Application

• ADME/Toxicology Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion profiles of isobutyrate and related compounds in preclinical models.
• Microbial Metabolism Research: Essential for tracing short-chain fatty acid (SCFA) production and utilization by gut microbiota, providing insights into host-microbiome interactions.
• Biochemical Pathway Elucidation: Enables detailed mapping of metabolic pathways involving isobutyryl-CoA and its role in branched-chain amino acid catabolism.
• Pharmaceutical Development: Supports the development of drugs targeting metabolic disorders by allowing precise quantification of compound turnover and metabolite formation.
• Environmental Fate Studies: Applied in research to track the degradation and environmental fate of isobutyrate derivatives.
• Synthesis of Labeled Compounds: Serves as a labeled building block for the synthesis of more complex carbon-14 labeled molecules for research.

Basic Information

Item	Details
Product Name	Isobutyric Acid Sodium Salt, [Carboxyl-14C]
CAS No.	6917-21-1
Molecular Formula	C4H714COONa
Molecular Weight	Contact for details
Synonyms	Sodium [1-14C]isobutyrate; Sodium 2-methyl[1-14C]propionate; [Carboxyl-14C]Isobutyric acid sodium salt; 2-Methyl[1-14C]propionic acid sodium salt; NSC 7615; Isobutyrate-1-14C sodium salt; Sodium isobutyrate-1-14C; Labeled sodium isobutyrate
EINECS	Contact for details

Quality Control

Every batch of our carbon-14 labeled Isobutyric Acid Sodium Salt is manufactured and analyzed under strict quality systems to ensure high radiochemical purity and specific activity. Quality assurance includes rigorous analysis via HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, radiochemical purity, chemical purity, and solvent content. Our production adheres to GLP (Good Laboratory Practice) principles to support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at or below -20°C. The product is hygroscopic (moisture-sensitive). Store in a dedicated, appropriately shielded area for radioactive materials in accordance with local radiation safety regulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (HPLC)	≥ 95%
Solvent (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.