Description

Epiberberine is a bioactive isoquinoline alkaloid derived from plants such as *Coptis chinensis* and *Phellodendron amurense*. This compound matters for its significant role as a key reference standard and active pharmaceutical ingredient (API) in research and development. Industries requiring high-purity natural product extracts, including pharmaceutical, nutraceutical, and academic research sectors, need it for quality control, bioactivity studies, and formulation development.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and purity testing of berberine-containing drugs and herbal extracts in QC laboratories.
• Metabolic Research: Serves as a critical tool in studying mechanisms related to glucose metabolism, insulin sensitivity, and metabolic syndrome.
• Natural Product Isolation & Analysis: Acts as a marker compound for the standardization and authentication of botanical raw materials like Goldthread and Amur Cork Tree bark.
• Dietary Supplement Formulation: Incorporated into high-end nutraceutical products targeting metabolic health and wellness.
• Biochemical & Pharmacological Screening: Utilized in in vitro and in vivo studies to investigate anti-inflammatory, antimicrobial, and potential anti-diabetic activities.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies on alkaloid chemistry and natural product pharmacology.

Basic Information

Product Name	Epiberberine
CAS No.	6873-09-2
Molecular Formula	C₂₀H₁₈NO₄⁺
Molecular Weight	336.36 g/mol
Synonyms	Epiberberine; 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium; (13aS)-2,3,9,10-Tetramethoxy-5,6,13,13a-tetrahydro-8H-dibenzo[a,g]quinolizin-8-one; 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizin-13-ium; Berberine, epi-; Isoberberine (ambiguous, verify context); A potential impurity of Berberine
EINECS	Contact for details

Quality Control

Our Epiberberine is produced and tested under strict quality management systems. Each batch undergoes comprehensive analysis including identification by spectroscopic methods (IR, NMR), purity determination by HPLC (typically ≥95% to ≥98%), and control of related substances. A Certificate of Analysis (COA) detailing all test results is provided to ensure traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0 %
Residue on Ignition	≤ 0.5 %
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.