Description

Pyridazine-D4 is a deuterated isotopologue of pyridazine, where four hydrogen atoms are replaced by deuterium, a stable isotope of hydrogen. This isotopic labeling is critical for applications requiring enhanced spectral resolution and metabolic stability in research. It serves as an essential building block and analytical standard for scientists in pharmaceutical development and advanced material science. The compound is particularly valuable for NMR spectroscopy and mass spectrometry studies in drug discovery and mechanistic research.

Application

• NMR Spectroscopy Internal Standard: Used as a chemical shift reference and solvent signal suppressor in proton and deuterium NMR analysis.
• Mass Spectrometry Tracer: Employed as a stable isotope-labeled internal standard for accurate quantification in LC-MS and GC-MS methods.
• Pharmaceutical Metabolism Studies: Acts as a non-radioactive tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• Mechanistic Reaction Studies: Utilized in kinetic isotope effect (KIE) studies to elucidate reaction mechanisms in organic and catalytic chemistry.
• Deuterated Material Synthesis: Serves as a precursor for synthesizing more complex deuterated compounds for specialized research applications.
• Analytical Reference Standard: Provides a high-purity certified reference material (CRM) for method development and validation in analytical laboratories.

Basic Information

Product Name	Pyridazine-D4
CAS No.	6830-40-6
Molecular Formula	C4D4N2
Molecular Weight	84.11 g/mol
Synonyms	1,2-Diazine-D4; o-Diazine-D4; [2H4]-Pyridazine; Perdeuterated Pyridazine; Tetradeuteropyridazine; Pyridazine-d4; 1,2-Diazabenzene-D4; Deutetraben-D4
EINECS	Contact for details

Quality Control

Every batch of Pyridazine-D4 is produced and analyzed under strict quality management protocols to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment (D-atom %), chemical purity, and solvent residue are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its sensitivity, the container should be kept sealed under an inert atmosphere when not in use to maintain isotopic integrity and prevent contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Isotopic Purity (D-atom %)	≥ 98% (by 1H NMR)
Chemical Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.