Description

Benzimidazole, 2-(2,2,2-Trifluoroacetamido)-4-(Trifluoromethyl)- is a specialized trifluoromethylated benzimidazole derivative, a high-value building block in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a benzimidazole scaffold with trifluoroacetamide and trifluoromethyl functionalities, offering significant potential for modulating the physicochemical properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where the introduction of fluorine atoms is a key strategy for enhancing metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for oncology, antiviral, and anti-inflammatory therapies, where the benzimidazole core is a privileged scaffold.
• Agrochemical Research: Serves as a key building block for developing new-generation fungicides, herbicides, and insecticides, leveraging the bioactivity of the benzimidazole moiety.
• Material Science: Used in the research and development of advanced organic electronic materials, such as OLEDs or charge-transport materials, due to its electron-deficient character from the trifluoromethyl groups.
• Fluorine Chemistry: An important reagent for introducing multiple fluorine atoms into complex molecules, enabling the study of structure-activity relationships (SAR) in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D programs.

Basic Information

Product Name	Benzimidazole, 2-(2,2,2-Trifluoroacetamido)-4-(Trifluoromethyl)-
CAS No.	6742-88-7
Molecular Formula	C10H5F6N3O
Molecular Weight	297.16 g/mol
Synonyms	2-(2,2,2-Trifluoroacetamido)-4-(trifluoromethyl)-1H-benzimidazole; 4-(Trifluoromethyl)-2-[(trifluoroacetyl)amino]-1H-benzimidazole; N-[4-(Trifluoromethyl)-1H-benzimidazol-2-yl]-2,2,2-trifluoroacetamide; 2-Trifluoroacetamido-4-trifluoromethylbenzimidazole
EINECS	Contact for details

Quality Control

Every batch of Benzimidazole, 2-(2,2,2-Trifluoroacetamido)-4-(Trifluoromethyl)- undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by IR and/or NMR), and impurity profile is provided with each shipment to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.