Description

Diisopropyl Phosphoramidite is a key organophosphorus reagent widely used as a versatile building block in organic synthesis. Its primary value lies in its role as a phosphitylating agent, enabling the efficient introduction of phosphorus-containing functional groups. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for the synthesis of oligonucleotides, ligands, and specialty catalysts.

Application

• Oligonucleotide Synthesis: A critical phosphitylating reagent in the solid-phase synthesis of DNA and RNA fragments for research, diagnostics, and therapeutic applications.
• Phosphine Ligand Precursor: Serves as an intermediate in the preparation of chiral and achiral phosphine ligands used in asymmetric catalysis and transition metal complexes.
• Agrochemical Intermediates: Employed in the synthesis of phosphorus-containing active ingredients for herbicides, insecticides, and plant growth regulators.
• Phosphoramidite Chemistry: A fundamental building block for creating custom phosphoramidites used in various nucleoside and nucleotide modifications.
• Polymer Additives: Used in the production of flame retardants and stabilizers for specialty polymers and plastics.
• Chemical Research: A valuable reagent for academic and industrial R&D in organophosphorus chemistry and methodology development.

Basic Information

Product Name	Diisopropyl Phosphoramidite
CAS No.	6415-20-9
Molecular Formula	C6H16NO2P
Molecular Weight	165.17 g/mol
Synonyms	Phosphoramidous Acid, Diisopropyl Ester; Diisopropyl Phosphoramidite; Diisopropylamino Phosphine Dioxide (incorrect but common); Diisopropyl Phosphoramidous Acid Ester; (Diisopropylamino)phosphine Oxide; H-Phosphonate Diisopropyl Ester (related); P(III) reagent; Phosphitylation Reagent
EINECS	229-150-4

Quality Control

Our Diisopropyl Phosphoramidite is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. While produced under GMP-like conditions for traceability, specifications can be tailored to meet specific research or cGMP requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C to minimize degradation. Due to its hygroscopic and easily oxidized nature, the container should only be opened in a moisture-free environment, such as a glovebox, and resealed immediately after use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC or NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.