Description

2-Iodo-5-Nitrothiophene is a versatile halogenated nitroheterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both an electron-withdrawing nitro group and a reactive iodine substituent on the thiophene ring, makes it a critical precursor for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of potential drug candidates, particularly in the development of antimicrobial, antiviral, and anticancer agents.
• Agrochemical Research: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the nitrothiophene scaffold.
• Material Science Precursor: Acts as a monomer or building block for conductive polymers, organic semiconductors, and non-linear optical (NLO) materials.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The iodine atom is highly reactive in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) for carbon-carbon bond formation.
• Functional Dye Development: Used in the synthesis of dyes and pigments with specific light-absorption or emission properties.

Basic Information

Product Name	2-Iodo-5-Nitrothiophene
CAS No.	6277-18-5
Molecular Formula	C4H2INO2S
Molecular Weight	254.03 g/mol
Synonyms	5-Nitro-2-iodothiophene; 2-Iodo-5-nitrothiophene; Thiophene, 2-iodo-5-nitro-; 2-Iodothiophene-5-nitro; 5-Nitro-2-iodo-thiophene; 2-Iodo-5-nitro-thiophene; 2-Iodo-5-nitro-thiophene (6CI,7CI,8CI); 2-Iodo-5-nitro-thiophene (9CI)
EINECS	Contact for details

Quality Control

Our 2-Iodo-5-Nitrothiophene is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.