Description

1-(Trimethylsilyl)-1-Propyne is a versatile organosilicon building block featuring a terminal alkyne group protected by a trimethylsilyl moiety. This compound is valued for its role as a stable, yet reactive, synthon in advanced organic synthesis, particularly in cross-coupling and cycloaddition reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular construction for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug molecules, especially in Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in creating novel active ingredients for crop protection agents, leveraging its alkyne functionality for structural diversity.
• Material Science: Serves as a monomer or precursor in the development of specialty polymers, silicon-containing dendrimers, and advanced organic electronic materials.
• Organic Synthesis Reagent: Employed as a protected acetylene equivalent in multi-step synthetic routes, allowing for selective deprotection and further functionalization.
• Chemical Research: A fundamental reagent in academic and industrial R&D for exploring new catalytic processes and constructing complex molecular architectures.

Basic Information

Product Name	1-(Trimethylsilyl)-1-Propyne
CAS No.	6224-91-5
Molecular Formula	C6H12Si
Molecular Weight	112.25 g/mol
Synonyms	Trimethylsilylacetylene; (Trimethylsilyl)acetylene; Ethynyltrimethylsilane; TMS-acetylene; 1-Trimethylsilyl-1-propyne; Prop-1-yn-1-yltrimethylsilane; TMSA; Silane, ethynyltrimethyl-
EINECS	228-310-5

Quality Control

Our 1-(Trimethylsilyl)-1-Propyne is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and highly volatile nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.