Description

Cbz-L-Valinol CAS NO 6216-65-5 is a protected amino alcohol derivative, specifically the carbobenzyloxy (Cbz) derivative of L-valinol. This compound serves as a crucial chiral building block and intermediate in sophisticated organic synthesis, particularly in the pharmaceutical and peptide chemistry sectors. Its primary value lies in providing a protected amine functionality, allowing for selective reactions and the construction of complex, optically active molecules. This makes it essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), peptide-based therapeutics, and other fine chemicals where stereochemical purity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of various drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a building block for introducing the valinol moiety into peptide chains, often after deprotection of the Cbz group.
• Ligand and Catalyst Preparation: Employed in the synthesis of chiral ligands for asymmetric catalysis and organocatalysts.
• Natural Product Synthesis: Serves as a starting material or intermediate in the total synthesis of complex natural products containing amino alcohol structures.
• Protecting Group Chemistry: The Cbz group can be selectively removed under mild hydrogenation conditions, making it valuable for multi-step synthetic sequences.
• Bioconjugation and Probe Development: Useful for creating labeled compounds or conjugates for biochemical and diagnostic applications.

Basic Information

Product Name	Cbz-L-Valinol
CAS No.	6216-65-5
Molecular Formula	C13H19NO3
Molecular Weight	237.29 g/mol
Synonyms	N-Carbobenzyloxy-L-valinol; (S)-2-(((Benzyloxy)carbonyl)amino)-3-methylbutan-1-ol; N-Cbz-L-valinol; N-[(Benzyloxy)carbonyl]-L-valinol; L-Valinol, N-[(phenylmethoxy)carbonyl]-; Benzyl N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]carbamate; Z-L-Valinol; CBZ-Valinol
EINECS	Contact for details

Quality Control

Our Cbz-L-Valinol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles. We can supply material compliant with various customer-specific specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.