Description

trans-2-Bromomethyl-1,3-Dioxolane-4-Methanol is a versatile brominated acetal derivative, primarily valued as a key chiral building block and intermediate in sophisticated organic synthesis. Its unique structure, featuring both a reactive bromomethyl group and a protected diol moiety, makes it essential for constructing complex molecular architectures with high stereochemical control. This compound is particularly critical for researchers and manufacturers in the pharmaceutical and fine chemical industries engaged in developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon for the synthesis of various drug candidates, particularly in nucleoside and carbohydrate chemistry.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Preparation: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer and Material Science: Employed in the synthesis of functionalized polymers and specialty monomers with tailored properties.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex fragrance and flavor compounds.

Basic Information

Product Name	trans-2-Bromomethyl-1,3-Dioxolane-4-Methanol
CAS No.	6204-43-9
Molecular Formula	C5H9BrO3
Molecular Weight	197.03 g/mol
Synonyms	4-(Hydroxymethyl)-2-(bromomethyl)-1,3-dioxolane (trans-); (2R,4S)- and (2S,4R)-2-(Bromomethyl)-4-(hydroxymethyl)-1,3-dioxolane; 2-Bromomethyl-4-hydroxymethyl-1,3-dioxolane; Bromoacetaldehyde Acetal of Glycerol; trans-2-Bromomethyl-4-hydroxymethyl-1,3-dioxolane; 1,3-Dioxolane-4-methanol, 2-(bromomethyl)-, trans-; Glycerol Bromoacetal
EINECS	Contact for details

Quality Control

Our trans-2-Bromomethyl-1,3-Dioxolane-4-Methanol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and consistent performance. We provide detailed Certificates of Analysis (COA) that include data for identity, assay, chiral purity, and impurity profiles, supporting compliance with cGMP and other relevant industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.