Description

Norleucine-5,5-D2, Ethyl Ester (9Ci) is a deuterium-labeled derivative of the amino acid norleucine, specifically designed for advanced research and analytical applications. This stable isotope-labeled compound is essential for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic pathway tracing. It is a critical material for pharmaceutical R&D, academic research, and contract research organizations (CROs) focused on proteomics, metabolomics, and pharmacokinetic studies.

Application

• Mass Spectrometry Internal Standard: Used for accurate quantification of norleucine and related compounds in complex biological matrices via LC-MS and GC-MS.
• Metabolic Research: Serves as a tracer in metabolic flux analysis and studies of amino acid metabolism, protein synthesis, and degradation pathways.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug candidates and their metabolites.
• Proteomics & Biomarker Discovery: Facilitates relative and absolute quantification (AQUA) of peptides and proteins in biomarker validation workflows.
• Nutritional Science Research: Applied in studies investigating amino acid absorption, utilization, and turnover in nutritional models.
• Chemical Synthesis Intermediate: Acts as a building block for the synthesis of more complex deuterium-labeled peptides or molecular probes.

Basic Information

Item	Detail
Product Name	Norleucine-5,5-D2, Ethyl Ester (9Ci)
CAS No.	6141-43-1
Molecular Formula	C8H15D2NO2
Molecular Weight	161.24 g/mol
Synonyms	L-Norleucine-5,5-d2 ethyl ester; Ethyl 2-amino-5,5-dideuteriohexanoate; 2-Amino-5,5-dideuteriohexanoic acid ethyl ester; Ethyl 2-aminohexanoate-5,5-d2; Norleucine-d2 ethyl ester; Hexanoic acid, 2-amino-5,5-d2-, ethyl ester; (S)-2-Amino-5,5-dideuteriohexanoic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Norleucine-5,5-D2, Ethyl Ester (9Ci) is produced under strict quality management protocols to ensure high chemical purity and isotopic enrichment. Each batch is characterized by NMR, mass spectrometry, and HPLC to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing all analytical results are provided and available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area%)
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.