Description

4-Fluoro-1-Butanesulfonyl Fluoride is a versatile organofluorine building block and sulfonyl fluoride reagent. This compound is valued for its dual reactive sites, enabling its use as a key intermediate in the synthesis of more complex sulfonamides and sulfonate esters. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecules and as a potential probe in chemical biology. The product is supplied under strict quality control to ensure batch-to-batch consistency for critical synthetic applications.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing sulfonyl fluoride or sulfonamide functional groups.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the fluorinated sulfonyl moiety is required for bioactivity.
• Chemical Biology Probe: Acts as a reactive handle in activity-based protein profiling (ABPP) due to the sulfonyl fluoride group's ability to covalently modify specific amino acids like serine.
• Material Science Research: Employed in the development of advanced polymers and functional materials, where the sulfonyl fluoride can be used for further derivatization or cross-linking.
• Organic Synthesis Building Block: Facilitates various carbon-fluorine and carbon-sulfur bond-forming reactions, enabling the construction of complex molecular architectures in medicinal chemistry.

Basic Information

Product Name	4-Fluoro-1-Butanesulfonyl Fluoride
CAS No.	660-14-0
Molecular Formula	C₄H₈F₂O₂S
Molecular Weight	158.17 g/mol
Synonyms	1-Butanesulfonyl fluoride, 4-fluoro-; 4-Fluorobutane-1-sulfonyl fluoride; 4-Fluorobutylsulfonyl fluoride; 4-Fluorobutanesulfonyl fluoride; 660-14-0; 4-FBSF; 4-Fluorobutan-1-sulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 4-Fluoro-1-Butanesulfonyl Fluoride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including assay by GC/HPLC, identity confirmation by FT-IR and/or NMR, and impurity profiling to ensure it meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its fluoride/strong alkali reactivity profile, ensure it is stored separately from bases and moisture-sensitive compounds.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.