Description

n-Butanesulfonyl Fluoride is a specialized organosulfur compound featuring a reactive sulfonyl fluoride functional group. This high-purity intermediate is critical for introducing the butanesulfonyl moiety into target molecules, enabling precise chemical modifications. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, proteomics research, and the synthesis of advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating sulfonamide-based drugs.
• Chemical Biology & Proteomics: Used as a reactive probe in activity-based protein profiling (ABPP) to study enzyme function and identify drug targets.
• Agrochemical Synthesis: Intermediate in the production of herbicides, fungicides, and other crop protection agents with sulfonyl-containing structures.
• Material Science: Employed in the surface modification of polymers and the creation of specialized coatings and adhesives.
• Cross-coupling Reactions: Serves as a coupling partner in palladium-catalyzed reactions for constructing complex organic molecules.
• Fluorination Reagent: Source of the fluorine atom in specific synthetic pathways for introducing fluorinated groups.

Basic Information

Product Name	n-Butanesulfonyl Fluoride
CAS No.	660-12-8
Molecular Formula	C₄H₉FO₂S
Molecular Weight	140.18 g/mol
Synonyms	1-Butanesulfonyl fluoride; Butane-1-sulfonyl fluoride; n-Butylsulfonyl fluoride; BSF; Butanesulfonic acid fluoride; NSC 401119; 660-12-8
EINECS	211-540-6

Quality Control

Our n-Butanesulfonyl Fluoride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters. We support compliance with relevant regulatory frameworks for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is moisture-sensitive and reacts with strong bases; ensure the container is kept tightly sealed to exclude moisture and stored separately from alkalis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Density	~1.2 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.