Description

1-Bromo-2-Fluorocyclohexane is a versatile halogenated cycloalkane building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of bromine and fluorine atoms on the cyclohexane ring, enabling selective functionalization and serving as a key intermediate for complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of fluorinated drug candidates, leveraging the fluorine atom to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, where the halogenated cyclohexane structure contributes to biological activity.
• Liquid Crystal & Advanced Material Precursor: Serves as a starting material for creating fluorinated liquid crystals and other specialty polymers with unique electronic or optical properties.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Negishi, or Stille couplings to form new carbon-carbon bonds.
• Nucleophilic Substitution Substrate: The secondary bromide is reactive towards various nucleophiles, allowing for the introduction of diverse functional groups onto the fluorinated ring system.
• Fluorine Chemistry Research: A valuable model compound for studying stereoelectronic effects and reaction mechanisms in alicyclic systems containing both bromine and fluorine.

Basic Information

Product Name	1-Bromo-2-Fluorocyclohexane
CAS No.	656-57-5
Molecular Formula	C6H10BrF
Molecular Weight	181.05 g/mol
Synonyms	2-Fluoro-1-bromocyclohexane; Bromofluorocyclohexane; Cyclohexane, 1-bromo-2-fluoro-; 1-Bromo-2-fluorocyclohexane; 656-57-5; NSC 377047; 2-Fluorocyclohexyl bromide
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluorocyclohexane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.4 g/cm³
Boiling Point	~65-70°C (at 15 mmHg)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.