Description

4-Trifluoromethyl-2,3,5,6-tetrafluorothiophenol is a highly fluorinated thiophenol derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring a perfluorinated aromatic ring and a reactive thiol group, makes it an essential precursor for introducing lipophilic and electron-withdrawing motifs into target molecules. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially those requiring trifluoromethylthio (-SCF₃) or perfluoroarylthioether linkages to modulate potency and ADMET properties.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorinated thiophenol moiety contributes to improved lipophilicity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science: Building block for fluorinated polymers, liquid crystals, and self-assembled monolayers (SAMs) to impart surface hydrophobicity and chemical resistance.
• Organic Electronics: Potential use in modifying the properties of semiconductors and charge-transport materials in OLEDs and OFETs.

Basic Information

Product Name	4-Trifluoromethyl-2,3,5,6-tetrafluorothiophenol
CAS No.	651-84-3
Molecular Formula	C7HF7S
Molecular Weight	250.13 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-(trifluoromethyl)benzenethiol; Pentafluorobenzene-4-thiol, Trifluoromethyl-; 4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzenethiol; Perfluoro(4-mercaptotoluene); α,α,α,2,3,5,6-Heptafluoro-4-thiocresol; 4-Mercapto-2,3,5,6-tetrafluoro-α,α,α-trifluorotoluene; 4-Trifluoromethyltetrafluorothiophenol
EINECS	211-476-5

Quality Control

Our 4-Trifluoromethyl-2,3,5,6-tetrafluorothiophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, impurity profile, and physical characteristics.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Due to its sensitivity to oxidation, the container should be purged with inert gas after each use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.