Description

Iodoacetonitrile is a versatile and highly reactive alkylating agent, primarily valued for its role as a key synthon in organic synthesis. Its core value proposition lies in its ability to introduce the cyano and iodo functional groups in a single step, facilitating the construction of complex molecules. This makes it an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of heterocyclic compounds and potential therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides, where its reactivity is leveraged to create novel molecular structures.
• Cross-Coupling Reactions: Serves as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Heck, Sonogashira) to form carbon-carbon bonds.
• Nucleophilic Substitution: The iodo group is readily displaced, making it a valuable reagent for alkylating amines, thiols, and other nucleophiles in fine chemical synthesis.
• Material Science Research: Employed in the surface modification of polymers and the synthesis of functionalized materials and liquid crystals.
• Bioconjugation & Labeling: Useful in biochemical research for modifying proteins, peptides, and other biomolecules due to its reactivity with sulfur and nitrogen nucleophiles.

Basic Information

Product Name	Iodoacetonitrile
CAS No.	624-75-9
Molecular Formula	C2H2IN
Molecular Weight	166.95 g/mol
Synonyms	Iodoacetonitrile; IAN; 2-Iodoacetonitrile; Acetonitrile, iodo-; Iodomethyl cyanide; Monoiodoacetonitrile; Cyanomethyl iodide; NSC 9375
EINECS	210-858-8

Quality Control

Our Iodoacetonitrile is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC and GC analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its highly volatile nature, keep the container tightly sealed when not in use and store at temperatures between 2°C and 8°C (refrigerated) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Specific Gravity (20°C)	2.20 - 2.30
Refractive Index (n20D)	1.540 - 1.545

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.