Description

3-Chloro-1-Propyne (CAS NO 624-65-7) is a versatile halogenated alkyne building block essential for advanced organic synthesis. Its reactive terminal alkyne and chlorine functionalities make it a critical intermediate for constructing complex molecular architectures. This compound is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as click chemistry, cross-coupling reactions, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via Sonogashira and other cross-coupling reactions.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides that require a propargylic chloride moiety.
• Click Chemistry Reagent: Serves as a valuable precursor in Huisgen cycloaddition and other click chemistry reactions to create triazole-based compounds.
• Polymer & Material Science: Acts as a monomer or functionalization agent for creating specialty polymers, dendrimers, and advanced materials with tailored properties.
• Ligand & Catalyst Development: Employed in the synthesis of novel ligands and organometallic catalysts for asymmetric synthesis and industrial catalysis.
• Organic Synthesis Building Block: Fundamental reagent for introducing the 3-chloropropynyl group into complex organic molecules in research and development.

Basic Information

Product Name	3-Chloro-1-Propyne
CAS No.	624-65-7
Molecular Formula	C3H3Cl
Molecular Weight	74.51 g/mol
Synonyms	Propargyl Chloride; 3-Chloropropyne; 1-Chloro-2-propyne; Chloromethylacetylene; 3-Chloro-1-propylene; γ-Chloroallylene
EINECS	210-852-0

Quality Control

Our 3-Chloro-1-Propyne is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat, sparks, and open flames. Due to its highly volatile nature, containers must be kept tightly sealed and upright. Recommended storage temperature is 2-8°C. Keep away from incompatible materials such as strong oxidizers, bases, and metals.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	1.03 - 1.06 g/mL
Boiling Point	57 - 59 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.