Description

1H-Indazole-1-Carboxylic Acid, 5-Amino-3-Methyl-, 1,1-Dimethylethyl Ester is a high-purity, protected amino indazole derivative serving as a critical synthetic intermediate. This compound matters for its role in constructing complex heterocyclic scaffolds, enabling the development of novel active pharmaceutical ingredients. It is primarily needed by research chemists and process development teams in the pharmaceutical and agrochemical industries for advanced synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other enzyme-related pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with potential therapeutic benefits.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new pesticides and herbicides with improved efficacy and environmental profiles.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological processes and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring protected indazole motifs.
• Academic Research: A valuable reagent for universities and research institutes exploring new heterocyclic chemistry and reaction methodologies.

Basic Information

Product Name	1H-Indazole-1-Carboxylic Acid, 5-Amino-3-Methyl-, 1,1-Dimethylethyl Ester
CAS No.	599183-32-1
Molecular Formula	C14H19N3O2
Molecular Weight	261.32 g/mol
Synonyms	tert-Butyl 5-Amino-3-methyl-1H-indazole-1-carboxylate; 5-Amino-3-methyl-1H-indazole-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-5-amino-3-methyl-1H-indazole; 3-Methyl-5-amino-1H-indazole-1-carboxylic acid 1,1-dimethylethyl ester; Boc-5-Amino-3-methylindazole; tert-Butyl 5-Amino-3-methylindazole-1-carboxylate; 5-Amino-3-methyl-1-Boc-indazole; 1-Boc-5-amino-3-methylindazole
EINECS	Contact for details

Quality Control

Our 1H-Indazole-1-Carboxylic Acid, 5-Amino-3-Methyl-, 1,1-Dimethylethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.