Description

Ethanone, 1-[(2R,5R)-2-Ethoxy-2,5-Dihydro-5-Methyl-2-Oxido-1,2-Oxaphosphol-3-Yl]-, Rel- (9Ci) is a specialized chiral organophosphorus compound that serves as a high-value intermediate in advanced synthetic chemistry. Its precise stereochemistry and unique oxaphosphole structure make it a critical building block for constructing complex molecules with defined spatial configurations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system or requiring specific stereochemical purity.
• Agrochemical Synthesis: Used in the production of advanced chiral pesticides and herbicides, where its structure contributes to the efficacy and environmental profile of the final product.
• Catalyst and Ligand Development: Serves as a precursor for novel organocatalysts or chiral ligands used in asymmetric synthesis, enhancing reaction selectivity and yield.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique optical or electronic properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms or biological pathways due to its phosphorus-containing functional group.
• Process Chemistry Optimization: Employed in route scouting and scale-up studies for the efficient, stereoselective manufacturing of complex organic molecules.

Basic Information

Product Name	Ethanone, 1-[(2R,5R)-2-Ethoxy-2,5-Dihydro-5-Methyl-2-Oxido-1,2-Oxaphosphol-3-Yl]-, Rel- (9Ci)
CAS No.	599179-50-7
Molecular Formula	C8H13O4P
Molecular Weight	204.16 g/mol
Synonyms	rel-(3R,5R)-3-Acetyl-5-methyl-2-ethoxy-2-oxido-1,2-oxaphospholane; (3R,5R)-3-Acetyl-5-methyl-2-ethoxy-1,2-oxaphospholan-2-one 2-oxide; 1-[(2R,5R)-2-Ethoxy-2,5-dihydro-5-methyl-2-oxido-1,2-oxaphosphol-3-yl]ethanone; (R,R)-2-Ethoxy-5-methyl-3-acetyl-1,2-oxaphospholane 2-oxide; Chiral Oxaphospholane Acetone Derivative; CAS 599179-50-7
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high stereochemical purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, 1H/31P/13C NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess (ee), and impurity profile is provided with every shipment. Our quality system is designed to support cGMP requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.