Description

6-Indolizinecarboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined bicyclic structure. This compound is of significant value in medicinal chemistry research and development, particularly for its potential role as a key building block in the synthesis of novel therapeutic agents. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new drug candidates, especially those targeting neurological and receptor-specific pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of potential active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug discovery programs.
• Ligand Synthesis: Employed in the development of selective ligands for biological receptors and enzymes due to its specific stereochemistry.
• Preclinical Development: Supplied for the synthesis of compounds used in pharmacological and toxicological testing.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis to construct complex nitrogen-containing heterocycles.

Basic Information

Item	Details
Product Name	6-Indolizinecarboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci)
CAS No.	588721-69-1
Molecular Formula	C14H15N3O
Molecular Weight	241.29 g/mol
Synonyms	(1R,3R,4S)-3-[(Indolizin-6-ylcarbonyl)amino]-1-azabicyclo[2.2.1]heptane; N-[(1R,3R,4S)-1-Azabicyclo[2.2.1]hept-3-yl]-1H-indolizine-6-carboxamide; (1R,3R,4S)-N-(1-Azabicyclo[2.2.1]hept-3-yl)indolizine-6-carboxamide; 6-Indolizinecarboxamide, N-(1-azabicyclo[2.2.1]hept-3-yl)-, (1R,3R,4S)-; A potential nicotinic acetylcholine receptor ligand intermediate.
EINECS	Contact for details

Quality Control

Every batch of 6-Indolizinecarboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci) is manufactured and tested under strict quality management systems to ensure identity, purity, and consistency. Our quality protocols are designed to meet the exacting standards of pharmaceutical development, with a focus on chiral purity and impurity profiling. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as assay (HPLC), chiral purity, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.