Description

1H-Indole-5-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci) is a high-purity, structurally complex organic compound featuring a fused indole-carboxamide moiety linked to a rigid azabicycloheptane scaffold. This molecular architecture is of significant interest for its potential as a key intermediate or active pharmaceutical ingredient (API) in advanced research and development. It is primarily sought after by pharmaceutical companies and advanced research institutions engaged in medicinal chemistry, particularly for the synthesis of novel therapeutics targeting neurological and central nervous system disorders. The compound, with CAS number 588703-48-4, represents a critical building block for innovators in the life sciences sector.

Application

This specialized chemical serves as a pivotal component in several high-value research and development applications:

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, particularly those targeting nicotinic acetylcholine receptors (nAChRs).
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of lead compounds.
• Neurological Disorder Research: Serves as a key scaffold for developing potential therapies for conditions such as Alzheimer's disease, Parkinson's disease, and neuropathic pain.
• Cognitive Enhancer Development: Investigated for its potential application in the design of nootropic agents and cognitive function modulators.
• Chemical Biology Probes: Utilized in the creation of selective molecular probes to study receptor function and signaling pathways in biological systems.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for Good Manufacturing Practice (GMP) production.

Basic Information

Product Name	1H-Indole-5-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci)
CAS No.	588703-48-4
Molecular Formula	C15H17N3O
Molecular Weight	255.32 g/mol
Synonyms	(1R,3R,4S)-1-Azabicyclo[2.2.1]hept-3-yl-1H-indole-5-carboxamide; (1R,3R,4S)-3-(1H-Indole-5-carboxamido)quinuclidine; 1H-Indole-5-carboxamide, N-[(1R,3R,4S)-1-azabicyclo[2.2.1]hept-3-yl]-; 588703-48-4; (1R,3R,4S)-N-(1-Azabicyclo[2.2.1]hept-3-yl)-1H-indole-5-carboxamide; TC-2559 (research code); TC 2559
EINECS	Contact for details

Quality Control

Our production of 1H-Indole-5-Carboxamide,n-(1R,3R,4S)-1-Azabicyclo[2.2.1]Hept-3-Yl-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. All materials are subjected to comprehensive analytical characterization using techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development from research to commercial scale with quality systems designed to meet the rigorous standards of the pharmaceutical industry.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (typically 15-25°C) in a cool, dry, and well-ventilated place. The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.