Description

1-Azabicyclo[2.2.2]Octan-3-Amine,2-Methyl-,(2R,3S)-(9Ci) is a high-purity, stereochemically defined bicyclic amine building block of significant interest in advanced organic synthesis. Its rigid, three-dimensional structure makes it a valuable scaffold for constructing complex molecules with specific spatial orientations. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and catalyst design.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets.
• Ligand Synthesis: Used in the preparation of sophisticated chiral ligands for asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained geometry.
• Agrochemical Development: Acts as a precursor in the creation of new crop protection agents with potentially novel modes of action.
• Chemical Biology Probes: Utilized to develop molecular probes for studying enzyme function and biological pathways.
• Advanced Material Synthesis: Investigated as a monomer or cross-linking agent for creating polymers with unique thermal or mechanical properties.

Basic Information

Product Name	1-Azabicyclo[2.2.2]Octan-3-Amine,2-Methyl-,(2R,3S)-(9Ci)
CAS No.	588702-77-6
Molecular Formula	C8H16N2
Molecular Weight	140.23 g/mol
Synonyms	(2R,3S)-2-Methyl-3-aminoquinuclidine; (2R,3S)-2-Methylquinuclidin-3-amine; (2R,3S)-3-Amino-2-methylquinuclidine; (2R,3S)-2-Methyl-1-azabicyclo[2.2.2]octan-3-amine; (2R,3S)-2-Methyl-3-aminobicyclo[2.2.2]octane; 2-Methyl-3-aminoquinuclidine (2R,3S)-isomer; Quinuclidine, 3-amino-2-methyl-, (2R,3S)-
EINECS	Contact for details

Quality Control

Every batch of 1-Azabicyclo[2.2.2]Octan-3-Amine,2-Methyl-,(2R,3S)-(9Ci) is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.