Description

tert-Butyl 3-Amino-5-Nitro-1H-Indazole-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a strategically protected indazole core. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition and other enzymatic pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical development.
• Chemical Biology Probes: Serves as a starting material for creating labeled compounds or probes used to study biological mechanisms and target engagement.
• Custom Synthesis: A foundational block for contract manufacturing organizations (CMOs) producing bespoke compounds for client-specific research needs.

Basic Information

Product Name	tert-Butyl 3-Amino-5-Nitro-1H-Indazole-1-Carboxylate
CAS No.	574729-25-2
Molecular Formula	C₁₂H₁₄N₄O₄
Molecular Weight	278.26 g/mol
Synonyms	1-Boc-3-amino-5-nitroindazole; tert-Butyl 3-amino-5-nitro-1H-indazole-1-carboxylate; 3-Amino-5-nitro-1H-indazole-1-carboxylic acid tert-butyl ester; 1H-Indazole-1-carboxylic acid, 3-amino-5-nitro-, 1,1-dimethylethyl ester; Boc-3-amino-5-nitroindazole; 5-Nitro-1H-indazol-3-amine, 1-Boc protected; 574729-25-2
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Amino-5-Nitro-1H-Indazole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with customer specifications and industry best practices for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.