Description

3-Ethynylbenzo[B]Thiophene is a high-value, functionalized heterocyclic building block characterized by its reactive ethynyl group fused to a benzo[b]thiophene core. This compound matters as a versatile synthon in advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and production of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Acts as a monomer or cross-linking agent in the development of advanced organic electronic materials, such as semiconductors for OLEDs or OFETs.
• Chemical Synthesis: Employed in Sonogashira, Huisgen cycloaddition (click chemistry), and other palladium-catalyzed coupling reactions to introduce the benzo[b]thiophene moiety.
• Ligand & Catalyst Development: Utilized to create novel ligands for transition metal catalysis or as a scaffold for organocatalysts.

Basic Information

Product Name	3-Ethynylbenzo[B]Thiophene
CAS No.	569353-00-0
Molecular Formula	C10H6S
Molecular Weight	158.22 g/mol
Synonyms	3-Ethynyl-1-benzothiophene; 1-Benzothiophen-3-ylethyne; 3-Ethynylbenzo[b]thiophene; 3-Ethynyl-1-benzothiophene; Benzo[b]thiophen-3-ylacetylene; 3-Ethynylbenzo[b]thiophene; 3-Ethynylbenzothiophene
EINECS	Contact for details

Quality Control

Our 3-Ethynylbenzo[B]Thiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the Certificate of Analysis. This product is easily oxidized and light-sensitive. Keep container tightly sealed in a cool, dry, and well-ventilated place. Separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.