Description

1H-Indazole-5-Thiol CAS NO 569339-86-2 is a high-purity sulfur-containing heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the reactive thiol (-SH) group attached to the indazole scaffold, enabling it to serve as a versatile intermediate for constructing complex molecular architectures. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and anticancer agent discovery.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and pesticides that require specific heterocyclic frameworks for bioactivity.
• Material Science Research: Serves as a precursor for ligands in catalysis or as a building block for advanced polymers and functional organic materials.
• Bioconjugation Chemistry: The thiol group allows for selective conjugation with maleimides or other electrophiles, useful in probe and linker molecule development.
• Chemical Biology Tool: Employed in the synthesis of activity-based probes for studying enzyme function and biological pathways.

Basic Information

Item	Details
Product Name	1H-Indazole-5-Thiol
CAS No.	569339-86-2
Molecular Formula	C7H6N2S
Molecular Weight	150.20 g/mol
Synonyms	5-Mercapto-1H-indazole; 1H-Indazole-5-thiol; 5-Indazolethiol; 5-Sulfanyl-1H-indazole; Indazole-5-thiol; 5-Mercaptoindazole; 1H-Indazol-5-yl mercaptan; 569339-86-2
EINECS	Contact for details

Quality Control

Our 1H-Indazole-5-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation. The compound is easily oxidized; prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.